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  • FDA approves leucovorin for ultrarare cerebral folate deficiency subset without clinical trial

FDA approves leucovorin for ultrarare cerebral folate deficiency subset without clinical trial

  • March 10, 2026

About five months after U.S. Health Secretary Robert F. Kennedy Jr. touted leucovorin as “an exciting therapy that may benefit large numbers of children who suffer from autism” during a White House press conference, the FDA has approved the decades-old drug for a rare genetic condition with “autistic features” that represents an ultrarare subset of autism patients.

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