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  • Ionis scraps early candidate for Alzheimer’s in people with Down syndrome

Ionis scraps early candidate for Alzheimer’s in people with Down syndrome

  • February 20, 2026

Ionis Pharmaceuticals has pulled the plug on an early investigational treatment for Alzheimer’s disease in people with Down syndrome, marking another setback for a group of patients who are both at higher risk for the neurodegenerative condition and not served by currently approved therapies.

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