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  • Merck’s $11B anti-TL1A bet delivers 1 win, 1 loss in midphase inflammatory disease trials

Merck’s $11B anti-TL1A bet delivers 1 win, 1 loss in midphase inflammatory disease trials

  • August 4, 2026

A phase 2 trial of Merck & Co.’s anti-TL1A monoclonal antibody has missed its primary endpoint, closing off one avenue for expansion of an asset acquired in a $10.8 billion takeover. The setback was offset by a midphase win in another indication.

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